POLA PERESEPAN OBAT ANTIHIPERTENSI DI POLI RAWAT JALAN RUMAH SAKIT “X” DI BALI PERIODE TAHUN 2022

Authors

  • Ni Nyoman Yudianti Mendra Universitas Mahasaraswati Denpasar
    Indonesia
  • I Gusti Ayu Puspasari Universitas Mahasaraswati Denpasar
    Indonesia
  • Nyoman Budiartha Siada Universitas Mahasaraswati Denpasar
    Indonesia
    https://orcid.org/0000-0002-0645-1529

DOI:

https://doi.org/10.23917/ujp.v3i2.311

Keywords:

Antihipertensi, Pola peresepan, rasionalitas terapi

Abstract

Hipertensi merupakan salah satu penyakit kronis dengan tingkat kejadian yang tinggi dan beresiko menyebabkan komplikasi. Pengobatan dan peresepan obat yang rasional diperlukan untuk mengontrol tekanan darah pasien serta mencegah terjadinya komplikasi. Penelitian ini bertujuan untuk mengetahui pola peresepan dan rasionalitas terapi antihipertensi pada pasien rawat jalan di salah satu rumah sakit umum di Bali tahun 2022 dengan BPJS sebagai jaminan asuransi kesehatan. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dimana teknik pengambilan sampelnya menggunakan purposive sampling. Kriteria inklusi dalam penelitian ini meliputi pasien hipertensi dengan dan tanpa komorbid, telah menjalani pengobatan minimal 3 bulan terapi pada periode Januari - Desember 2022. Rasionalitas terapi meliputi tepat obat, tepat pasien, tepat dosis, dan tepat interval waktu pemberian yang dinilai berdasarkan pedoman JNC 8 dan Konsensus Penatalaksanaan Hipertensi Tahun 2021. Berdasarkan data dari 368 pasien rawat jalan, antihipertensi yang diresepkan meliputi Angiotensin receptor blocker (ARB) dengan persentase 64,13%; Calsium Channel Blocker (CCB) 59,51%; Angiotensin Converting Enzim Inhibitor (ACEI) 16,85%; Beta Blocker 15,22% dan diuretik sebesar 0,81%. Pada hasil evaluasi peresepan obat antihipertensi diperoleh tepat obat sebanyak 98,64%, tepat pasien sebanyak 96,74%, tepat dosis sebanyak 100%, dan tepat interval waktu pemberian sebanyak 100%.

Downloads

Download data is not yet available.

References

Abraham, G., Arun, K.N., Gopalakrishnan, N., Renuka, S., Pahari, D.K., Deshpande, P., Isaacs, R., Chafekar, D.S., Kher, V., Almeida, A.F., Sakhuja, V., Sundar, S., Gulati, S., Abraham, A., Padmanaban, R., 2017, Management of Hypertension in Chronic Kidney Disease: Consensus Statement by an Expert Panel of Indian Nephrologists, The Journal of the Association of Physicians of India, 6-22.

Ali, N., Mahmood, S., Islam, F., Rahman, S., Haque, T., Islam, S., Rahman, S., Haque, N., Mosaib, G., Perveen, R., Khanum, F.A., 2019, Relationship between Serum Uric Acid and Hypertension: a Cross-Sectional Study in Bangladeshi Adults, Scientific Reportseports, 9(1), pp. 1–7. Available at: https://doi.org/10.1038/s41598-019-45680-4.

Bakris, G.L., Hart, P. and Ritz, E., 2006, Beta Blockers in The Management of Chronic Kidney Disease, Kidney International, 70, 1905–1913. Available at: https://doi.org/10.1038/sj.ki.5001835.

Carnovale, C., Gringeri, M., Battini, V., Mosini, G., Invernizzi, E., Mazhar, F., Bergamaschi, F., Fumagalli, M., Zuccotti, G., Clementi, E., Radice, S., Fabiano, V., 2021, Beta-blocker-associated Hypoglycaemia: New Insights from a Real-World Pharmacovigilance Study, British Journal of Clinical Pharmacology, 87, pp. 3320–3331. Available at: https://doi.org/10.1111/bcp.14754.

Destiani, D.P., and Rhofianingrum, R.l., 2016, Evaluasi Penggunaan Obat Antihipertensi Pada Pasien Rawat Jalan Di Fasilitas Kesehatan Rawat Jalan Pada Tahun 2015 Dengan Metode ATC/DDD, Farmaka,14(2), pp. 19–25. Available at: https://doi.org/https://doi.org/10.24198/jf.v14i2.928 7.g4161.

Finks, S.W., Rumbak, M.J., and Self, T.H., 2020, Treating Hypertension in Chronic Obstructive Pulmonary Disease, The New England Journal of Medicine, 382(4), pp. 353–363. Available at: https://doi.org/10.1056/nejmra1805377.

Gois, P.H.F., Souza, E.R. de M., and Santos, C.U., 2010, Pharmacotherapy for Hyperuricemia in Hypertensive Patients, Cochrane Database of Systematic Reviews [Preprint], (4). Available at: https://doi.org/10.1002/14651858.cd008652.

Imaizumi, Y., Eguchi, K., and Kario, K., 2015, Lung Disease and Hypertension, Pulse, 2(1–4), pp. 103–112. Available at: https://doi.org/10.1159/000381684.

Iorga, A., Cunningham, C.M., Moazeni, S., Ruffenach, G., Umar, S., Eghbali, M., 2017, The Protective Role of Estrogen and Estrogen Receptors in Cardiovascular Disease and The Controversial Use of Estrogen Therapy, Biology of Sex Differencesifferences, 8(1), pp. 1–16. Available at: https://doi.org/10.1186/s13293-017-0152-8.

James, P.A., Oparil, S., Carter, B.L., Cushman, W.C., Dennison, H.C., Handler, J., Lackland, D.T., LeFevre, M.L., MacKenzie, T.D., Ogedegbe, O., Smith, S.C. Jr., Svetkey, L.P., Taler, S.J., Townsend, R.R., Wright, J.T.Jr., Narva, A.S., Ortiz, E., 2014, Evidence-based Guideline for The Management of High Blood Pressure in Adults: Report from The Panel Members Appointed to The Eighth Joint National Committee (JNC 8), American Medical Association, 311(5), pp. 507–520. Available at: https://doi.org/10.1001/jama.2013.284427.

Kemenkes RI., 2011, Modul Penggunaan Obat Rasional, Kementerian Kesehatan RI, Jakarta.

Kemenkes RI., 2019, Laporan Riskesdas 2018 Nasional, Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan, Jakarta. Available at: https://www.badankebijakan.kemkes.go.id/lapor an-hasil-survei/%0Ahttps://repository.badankebijakan.kemkes.go.id/id/eprint/3514/.

KDIGO., 2012, Clinical Practice Guideline for The Management of Blood Pressure in Chronic Kidney Disease, Kidney International Supplements, 2(5), pp. 337–414. Available at: https://doi.org/ 10.1038/kisup.2012.46.

Kim, S.H., Shin, D.W., Kim, S., Han, K., Park, S.H., Kim, Y.H., Jeon, S.A., and Kwon, Y.C., 2019, Prescribing Patterns of Antihypertensives for Treatment-Naïve Patients in South Korea: From Korean NHISS Claim Data, International Journal of Hypertension, pp. 1–10. Available at: https://doi.org/10.1155/2019/4735876.

Kohro, T., Yamazaki, T., Sato, H., Ohe, K., and Nagai, R., 2013, The Impact of a Change in Hypertension Management Guidelines on Diuretic Use in Japan: Trends in Antihypertensive Drug Prescriptions from 2005 to 2011, Hypertension Research, 36(6), pp. 559–563. Available at: https://doi.org/10.1038/hr.2012.216.

Lima, R., Wofford, M., and Reckelhoff, J.F., 2012, Hypertension in Postmenopausal Women, Current Hypertension Reports, 14(3), pp. 254–260. Available at: https://doi.org/10.1007/s11906-012-0260-0.

Lukito, A.A., Harmeiwaty, E., Hustrini, N.M., 2021, Konsensus Penatalaksanaan Hipertensi 2021: Update Konsensus PERHI 2019, Perhimpunan Dokter Hipertensi Indonesia. Jakarta.

Lukito, A.A., Harmeiwaty, E. and Hustrini, N.M., 2019, Konsensus Penatalaksanaan Hipertensi 2019, Perhimpunan Dokter Hipertensi Indonesia, Jakarta.

National Kidney Foundation., 2010, High Blood Pressure and Chronic Kidney Disease, National Kidney Foundation, New York. Available at: http://www.kidney.org/atoz/pdf/hbpandckd.pdf.

Nurfanni, R., 2021, Deskripsi Karakteristik Responden, Penyakit Penyerta dan Kepatuhan Kontrol Penderita Hipertensi, Skripsi, Fakultas Ilmu Kesehatan, Universitas Muhhamadiyah Surakarta, Surakarta.

Ompusunggu, W., 2021, Evaluasi Peresepan Obat Antihipertensi Di Puskesmas Desa Pon Kabupaten Serdang Bedagai Periode Juli-September 2020, Skripsi, Fakultas Farmasi, Universitas Sanata Dharma, Yogyakarta.

Pertiwi, M.D., Martini, S., Artanti, K.D., Widatir, S., 2022, The Relationship of Hypertension, Genetic and Degree of Smoking With the Incidence of Copd At Haji Public Hospital Surabaya’, Indonesian Journal of Public Health, 17(2), pp. 241–251. Available at: https://doi.org/10.20473/ij ph.v17i2.2022.241-251.

Polopadang, Y., Mongi, J., Maarisit, W., Karuawan,F., 2021, Pola Peresepan Penggunaan Obat Antihipertensi di UPTD Puskesmas Airmadidi, The Tropival Journal of Biopharmaceutical, 4(1), pp. 97–101. Available at: https://doi.org/https://doi.org/10.55724/j.biofar.trop.v4i1.315.

Pugh, D., Gallacher, P.J., and Dhaun, N., 2019, Management of Hypertension in Chronic Kidney Disease, Drugs, 79, pp. 365–379. Available at: https://doi.org/10.1007/s40265-019-1064-1.

Puspitasari, P.N., 2020, Hubungan Hipertensi Terhadap Kejadian Stroke, Jurnal Ilmiah Kesehatan Sandi Husada, 12(2), pp. 922–926. Available at: https://doi.org/10.35816/jiskh.v12i2.435.

Schwinghammer., Terry, L., Joseph, T., DiPiro, Pharm. D., 2021, Pharmacotherapy Handbook Eleventh, McGraw Hill, New York.

Soenarta, A.A., Erwinanto., Mumpuni, A.S.S., Barack, R., Lukito, A.A., Hersunarti, N., Pratikto, R.S., 2015, Pedoman Tatalaksana Hipertensi pada Penyakit Kardiovaskular, Perhimpunan Dokter Spesialis Kardiovasular Indonesia, Jakarta. Available at: https://doi.org/10.1103/PhysRe vD.42.2413.

Sugiyono., 2019, Metode Penelitian Kuantitatif, Kualittatif, dan R&D, Alfabeta, Bandung.

Sumawa, P.M.R., Wullur, A.C., and Yamlean, P.V.Y., 2015, Evaluasi Kerasionalan Penggunaan Obat Antihipertensi pada Pasien Hipertensi Rawat Inap di RSUP Prof. Dr. R.D. Kandou Manado Periode Januari-Juni 2014, Pharmacon Jurnal Ilmiah Farmasi-UNSRAT, 4(3), pp. 126–133. Available at: https://doi.org/https://doi.org/10.35799/pha.4.2015.8850.

Tsujimoto, T., Sugiyama, T., Shapiro, M.F., Noda, M., Kajio, H., 2017, Risk of Cardiovascular Events in Patients with Diabetes Mellitus on β-Blockers, American Heart Association, pp. 103–110. Available at: https://doi.org/10.1161/HYPERTENSIONAHA.117.09259.

Tuloli, T.S., Rasdianah, N. and., Tahala, F., 2021, Pola Penggunaan Obat Antihipertensi Pada Pasien Hipertensi, Indonesian Journal of Pharmaceutical Education, 1(2), pp. 127–135. Available at: https://doi.org/10.37311/ijpe.v1i3.11083.

WHO., 2024, Promoting Rational Use of Medicine, World Health Organization. Available at: https://www.who.int/activities/promoting-rational-use-of-medicines (Accessed: 16 January 2024).

Xu, H., He,Y., Xu, L., Yan, X., Dai, H., 2015, Trends and Patterns of Five Antihypertensive Drug Classes between 2007 and 2012 in China Using Hospital Prescription Data, International Journal of Clinical Pharmacology and Therapeutics, 53(6), pp. 430–437. Available at: https://doi.org/10.5414/CP2 02243.

Yılmaz, İ., 2019, Angiotensin-Converting Enzyme Inhibitors Induce Cough, Turkish Thoracic Journal, 20(1), pp. 36–42. Available at: https://doi.org/10.5152/TurkThoracJ.2018.18014

Downloads

Published

2024-07-29

How to Cite

Mendra, N. N. Y., Puspasari, I. G. A. ., & Siada, N. B. (2024). POLA PERESEPAN OBAT ANTIHIPERTENSI DI POLI RAWAT JALAN RUMAH SAKIT “X” DI BALI PERIODE TAHUN 2022 . Usadha Journal of Pharmacy, 3(2), 148–161. https://doi.org/10.23917/ujp.v3i2.311

Issue

Section

Articles